53.  Florent Larnaud, Adamo Sulpizi, Nicklas O. Häggman, Jonathan M.E. Hughes, Damien F. Dewez and James L. Gleason
Organocatalytic Michael Addition of Indoles to alpha-Substituted Enals Using a Diazepane Carboxylate Catalyst
Eur. J. Org. Chem.
2017, 18, 2637-2640





52.  Dainis Kaldre and James L. Gleason
An Organocatalytic Cope Rearrangement
Angew. Chem., 2016, 55, 11557-115561





For a highlight of this work, see: Angew. Chem. Int. Ed. 2016, 55, 14208-14209

51. James L. Gleason and John H. White
Bifunctional Vitamin D. Hybrid Molecules
Vitamin D: 4th edition. Feldmen, Pike, Bouillon, Givannucci, Goltzman, Hewison, eds. in press


50. Tatiana Traboulsi, Mohamed El Ezzy, James L. Gleason, Sylvie Mader
Mechanisms of Action of Antiestrogens: Impact on Clinical Use
J. Mol. Endo., 2017, 58, R15-31









49. Lee D. Fader, Martine Brault, Jessica Desjardins, Nathalie Dansereau, Louie Lamorte, Sonia Tremblay, François Bilodeau, Josée Bordeleau, Martin Duplessis, Vida Gorys, James R. Gillard, James L Gleason, Clint James, Marc-André Joly, Cyrille Kuhn, Montse Llinas-Brunet, Laibin Luo, Louis Morency, Sébastien Morin, Mathieu Parisien, Maude Poirier, Carl Thibeault, Thao Trinh, Claudio Sturino, Sanjay Srivastava, Christiane Yoakim, and Michael Franti
Discovery of Potent, Orally Bioavailable Inhibitors of Human Cytomegalovirus
ACS Med. Chem. Lett., 2016, 7, 525-530









48. Rodrigo Mendoza-Sanchez, David Cotnoir-White, Justyna Kulpa, Isabel Jutras, Joshua Pottel, Nicolas Moitessier, Sylvie Mader and James L. Gleason
Design, Synthesis and Evaluation of Antiestrogen and Histone Deacetylase Inhibitor Molecular Hybrids
Bioorg. Med. Chem. 2015, 24, 7597-7606


47. Dainis Kaldre, Tian-Tian Wang, Joshua Fischer, John H. White and James L. Gleason
Optimization of Histone Deacetylase Inhibitor Activity in Non-Secosteroidal Vitamin D Receptor Agonist Hybrids
Bioorg. Med. Chem., 2015, 23, 5035-5049






46. Shuo Xing and James L. Gleason
A Robust Synthesis of N-Glycolyl Muramyl Dipeptide via Azidonitration/Reduction
Org. Biomol. Chem. 2015, 13, 1515-1520






45. Nicolas De Rycke, Jeffrey D. St Denis, Jonathan M.E. Hughes, Kristopher A. Rosadiuk and James L. Gleason
Direct Intramolecular Catalytic Enantioselective Alkylation of Oxazolidinone Bomoalkanoate Imides
Synlett, 2014, 25, 2802-2805






44. Joshua Pottel, Eric Therrien, James L. Gleason and Nicolas Moitessier
Docking Ligands into Flexible and Solvated Macromolecules. 6. Development and Application to the Docking of HDACs and other Zinc Mettaloenzyme Inhibitors
J. Chem. Info. Model. 2014, 54, 254-265






43. Erica Tiong, Daniel Rivalti, Benjamin M. Williams and James L. Gleason
A Concise Total Synthesis of (R)-Puraquinonic Acid.
Angew. Chem. Int. Ed., 2013, 52, 3442-3445



42. Kyle F. Biegasiewicz, Michelle L. Ingalsbe, Jeffrey D. St. Denis, James L. Gleason, Junming Ho, Michelle L. Coote, G. Paul Savage and Ronny Priefer
Evaluation of a chiral cubane-based Schiff base ligand in asymmetric catalysis reactions
Beilstien J. Org. Chem. 2012, 8, 1814-1818




41. Khalid Hilmi, Nader Hussein, Rodrigo Mendoza-Sanchez, Mohammed El-Ezzy, Houssam, Ismail, Chantal Durette, Martine Bail, Maria Johanna Rozendaal, Michel Bouver, Pierre Thibault, James L. Gleason and Sylvie Mader
Role of SUMOylation in full antiestrogenicity
Molecular and Cellular Biology 2012, 32, 3823-3837



40. Joshua Fischer, Tian-Tian Wang, Dainis Kaldre, Natacha Rochel, Dino Moras, John H. White and James L. Gleason
Synthetically accessible non-secosteroidal hybrid molecules combining vitamin D receptor agonism and histone deacetylase inhibition
Chemistry and Biology, 2012, 19, 963-971.



39. Erica Tiong and James L. Gleason
Section 20.2.1.8.14: Synthesis of Carboxylic acids: alpha-alkylation
Science of Synthesis
2011, 4, 283-299. 



38. Marc Lamblin, Russell Spingarn, Tian-Tian Wang, Melanie C.Burger, Basel Dabbas, Nicolas Moitessier, John H. White and James L. Gleason
An o-aminoanilide analog of 1-alpha,25-dihydroxyvitamin D3 functions as a strong vitamin D receptor antagonist.
J. Med. Chem. 2010, 53, 7461-7465.



37. Marc Lamblin, Basel Dabbas, Russell Spingarn, Rodrigo Mendoza-Sanchez, Tian-Tian Wang, Beum-Soo An, Dao Chao Huang, Richard Kremer, John H. White and James L. Gleason.
Vitamin D Receptor Agonists/Histone Deacetylase Inhibitor Molecular Hybrids
Bioorg. Med. Chem. 2010, 18, 4119-4137.


36. James A. Ashenhurst, Ljubomir Isakovic and James L. Gleason
Application of a [6+4] cycloaddition strategy toward the total synthesis of CP-225,917
Tetrahedron 2010, 66, 368-378.



35. Michelle L. Ingalsbe, Jeffrey D. St. Denis, James L. Gleason, Paul G. Savage, Ronny Priefer,
Synthesis of novel chiral cubane-based Schiff-base ligand and it's application in asymmetric nitro aldol (Henry) reaction
Synthesis 2010, 98-102.



34. Francois Coulombe, Maziar Divangahi, Frederic Veyrier, James L. Gleason, Yibin Yang, Michelle A. Kelliher, Amit K. Pandey, Christopher M. Sassetti, Michael B. Reed, Marcel A. Behr
Increased NOD2-Mediated Recognition of N-Glycolylated Muramyl Dipeptide
J. Exper. Med. 2009, 206, 1709-1716.




33. Erica A. Tiong and James L. Gleason
Stereoselective Formation of alpha-Quaternary Stereocenters in the Mannich Reaction.
Org. Lett. 2009, 11, 1725-1728



 

32. Jonathan Hudon, Timothy A. Cernak, James A. Ashenhurst and James L. Gleason
Stable 5-Substituted Cyclopentadienes for the Diels-Alder Cycloaddition and their Application to Palauamine Synthesis
Angew. Chem. Int. Ed. 2008, 47, 8885-8888



31. Luz E. Tavera-Mendoza, Tan D. Quach, Basel Dabbas, Jonathan Hudon, Xiaohong Liao, Ana Palijan James L. Gleason and John H. White
Incorporation of histone deacetylase inhibition into the structure of a nuclear receptor agonist.
Proc. Nat. Acad. Sci. 2008, 105, 8250-8255



30. James A. Ashenhurst and James L. Gleason
CP-225,917 Synthetic Studies: Unusual Hydroboration Regioselectivity Influenced by Remote Functional Groups
Tetrahedron Lett. 2008, 49, 504-507



29. Timothy Cernak and James L. Gleason
Density Functional Theory Guided Design of Exo-Selective Dehydroalanine Dienophiles for Application Towards the Synthesis of Palau'amine
J.Org. Chem. 2008, 73, 102-110.



28. Timothy Cernak and James L. Gleason
Synthesis of 5-Chloromethylene Hydantoins and Thiohydantoins
Heterocycles 2007, 71, 117-134



27. Azélie Arpin, Jeffrey M. Manthorpe and James L. Gleason
A Practical Bicylic Lactam Auxiliary for Quaternary Carbon Formation
Organic Letters, 2006, 8, 1359-1362




26. Jeremy D. Cheeseman, Andrew D. Corbett, James L. Gleason* and Romas J. Kazlauskas*
Receptor-Assisted Combinatorial Chemistry: Thermodynamics and Kinetics in the Discovery of Tight-Binding Molecules
Chem. Eur. J., 2005, 11, 1708-1716




25. E. Diane Burke and James L. Gleason
alpha,alpha-Disubstituted Boron Enolates in the Asymmetric Synthesis of Quaternary Carbon Centers
Org. Lett., 2004, 6, 405-407




24. James L. Gleason and Alain Ajamian
Two Birds with One Metallic Stone: Single-Pot Catalysis of Fundamentally Different Transformations
Angew. Chem. Int. Ed., 2004, 43, 3754-3760



23. Andrew D. Corbett, Jeremy D. Cheeseman, Romas J. Kazlauskas* and James L. Gleason*
Pseudo-Dynamic Combinatorial Libraries: A New Receptor-Assisted Combinatorial Approach for Drug Discovery
Angew. Chem. Int. Ed., 2004, 43, 2432-2436




22. Alain Ajamian and James L. Gleason
Cobalt Catalyzed Cycloisomerizations of 1,6-Enynes and Allyl Propargyl Ethers
Organic Letters, 2003, 5, 2409-2411.




21. E. Diane Burke, Ngiap Kie Lim and James L. Gleason
Catalytic Enantioselective Homoaldol Reactions Using Binol Titanium (IV) Fluoride Catalysts
Synlett, 2003, 390-392




20. Jeffrey M. Manthorpe and James L. Gleason
Stereoselective Formation of Quaternary Carbon Centres: Alkylation of alpha,alpha-Disubstituted Amide Enolates
Angew. Chem. Int. Ed., 2002, 41, 2338-2341.




19. Jeremy D. Cheeseman, Andrew D. Corbett, Ronghua Shu Jonathan Croteau, James L. Gleason* and Romas J. Kazlauskas*
Amplification of Screening Sensitivity Through Selective Destruction. Theory and Screening of a Library of Carbonic Anhydrase Inhibitors
J. Am. Chem. Soc., 2002, 124, 5692-5701.




18. Andrew D. Corbett and James L. Gleason
Preparation of Active Esters on Solid Support for Aqueous Phase Peptide Couplings
Tetrahedron Letters, 2002, 43, 1369-1372.




17. Ljubomir Isakovic, James A. Ashenhurst and James L. Gleason
Application of Lewis Acid Catalyzed Tropone [6+4] Cycloadditions to the Synthesis of the Core of CP-225,917
Organic Letters, 2001, 3, 4189-4192




16. Alain Ajamian and James L. Gleason
Diastereoselective Synthesis of 2H,5H-Dihydrofurans by Cobalt Mediated Cycloisomerization of Allyl Propargyl Ethers. Application to Poly-THF Molecules
Organic Letters, 2001, 3, 4161-4164


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15. Jeffrey M. Manthorpe and James L. Gleason
Stereoselective Generation of Disubstituted Enolates; Reductive Enolization of Bicylic alpha-Thioglycolate Lactams
J. Am. Chem. Soc. 2001, 123, 2091-2092



14. Régis Dolaine and James L. Gleason
Diastereoselective Formation of 5-Vinylcyclopentenes from 1,6-Enynes: Cobalt Mediated C-H Allylic Activation and Formal 5-Endo-Dig Cyclization
Organic Letters, 2000, 2, 1753-1756



13. Evelyn O. Martins and James L. Gleason
Titanium (IV) Triflates in the Catalysis of Homoaldol Reactions
Organic Letters 1999, 1, 1643-1645



12. Andrew G. Myers and James L. Gleason
Asymmetric Synthesis of alpha-Amino Acids by the Alkylation of Pseudoephedrine Glycinamide. Preparation of L-Allylglycine and N-Boc L-Allylglycine
Org. Syn., 1999, 76, 57-76

11. Andrew G. Myers, Lydia McKinstry, Joseph K. Barbay, and James L. Gleason
Practical Methodology for the Asymmetric Synthesis of Organofluorine Compounds
Tetrahedron Lett. 1998, 39, 1335-1338

10. Andrew G. Myers, Lydia McKinstry and James L. Gleason
Synthesis of Tertiary Alkyl Fluoride Centers by Asymmetric C-C(F) Bond Formation
Tetrahedron Lett., 1997, 38, 7037-7040

9. Robert E. Ireland, Longbin Liu, Thomas D. Roper and James L. Gleason
Total Synthesis of FK-506. 2. Completion of the Synthesis
Tetrahedron, 1997, 53, 13257-13284

8. Andrew G. Myers, Bryant H. Yang, Hou Chen, Lydia Mckinstry, David J. Kopecky and James L. Gleason
Pseudoephedrine as a Practical Chiral Auxiliary for the Synthesis of Highly Enantiomerically Enriched Carboxylic Acids, Alcohols, Aldehydes and Ketones
J. Am. Chem. Soc., 1997, 119, 6496-6511

7. Andrew G. Myers, James L. Gleason, Taeyoung Yoon, and Daniel W. Kung
Highly Practical Methodology for the Synthesis of D- and L- alpha-Amino Acids, N-Protected alpha-Amino Acids, and N-Methyl alpha-Amino Acids
J. Am. Chem. Soc., 1997, 119, 656-673

6. Robert E. Ireland, James L. Gleason, Laura D. Gegnas and Thomas K. Highsmith
A Total Synthesis of FK-506
J. Org. Chem. 1996, 61, 6856-6872

5. Andrew G. Myers and James L. Gleason
A Practical Synthesis of Azatyrosine
J. Org. Chem. 1996, 61, 813-815

4. Andrew G. Myers, James L. Gleason and Taeyoung Yoon
A Practical Method for the Synthesis of D- or L-alpha-Amino Acids by the Alkylation of (+)- or (­)-Pseudoephedrine Glycinamide
J. Am. Chem. Soc. 1995, 117, 8488-8489

3. Andrew G. Myers, Taeyoung Yoon and James L. Gleason
A One-Step Synthesis of Pseudoephedrine Glycinamide, a Versatile Precursor for the Synthesis of alpha-Amino Acids
Tetrahedron Lett. 1995, 36, 4555-4558

2. Andrew G. Myers, Bryant H. Yang, Hou Chen and James L. Gleason
Use of Pseudoephedrine as a Practical Auxiliary Asymmetric Synthesis
J. Am. Chem. Soc. 1994, 116, 9361-9362

1. Robert E. Ireland, Thomas K. Highsmith, Laura D. Gegnas James L. Gleason
Synthesis of the 9,10-Acetonide of 9-Dihydro-FK-506
J. Org. Chem. 1992, 57, 5071-5073

 
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