70. Josephine M. Warnica and James. L. Gleason Mimicking enzymatic cation–π interactions in hydrazide catalyst design: access to trans-decalin frameworks Chem. Commun. 2023, Advance Article 69. Ryan R. G. Barrett, Donald A. Campbell and James L. Gleason An Organocatalytic oxy-Cope/Michael cascade Reaction Org. Lett. 2023, 25, 777-781 68. Anthony R. Izzotti and James L. Gleason Do Antarafacial Cycloadditions Occur? Cycloaddition of Heptafulvalene with Tetracyanoethylene.  Chem. Eur. J. 2022, 28, e202201418 67. Camille Barbier, Ali Mansour, Aiten Ismailova, Parvaneh Sarmadi, David A. Scarlata, Manuella Bouttier, Camille Zeitouni, Catherine Wang, James L. Gleason and John H. White  Molecular mechanisms of bifunctional vitamin D receptor agonist-histone deacetylase inhibitor hybrid molecules in triple-negative breast cancer. Scientific Reports 2022, 12, 6745-6757 66. Samuel J. Plamondon and James L. Gleason Total Synthesis of (–)-3-Oxoisotaxodione Org. Lett. 2022, 24, 2305-2309 65. Josephine M. Warnica and James L. Gleason The Stabilized Iminium Catalyzed (E)-Polyene Cyclization: Trapping of Non-Activated Terminating Groups Enabled by Cation-π Interactions Can. J. Chem. 2022, 100, 212-216 64. Ryan R.G. Barrett, Claire Nash, Marine Diennet, David Cotnoir-White, Christopher Doyle, Sylvie Mader, Axel A. Thomson, James L. Gleason Dual-function antiandrogen/HDACi hybrids based on enzalutamide and entinostat Bioorg. Med. Chem. Lett. 2022, 55, 128441 63. Jacob N. Sanders, HyunJune Jun, Roland A. Yu, James L. Gleason and K. N. Houk Mechanism of an Organocatalytic Cope Rearrangement Involving Iminium Intermediates: Elucidating the Role of Catalyst Ring Size J. Am. Chem. Soc. 2020, 142, 16877-16886 62. Samuel J. Plamondon, Josephine M. Warnica, Dainis Kaldre and James L. Gleason Hydrazide-Catalyzed Polyene Cyclization: Asymmetric Organocatalytic Synthesis of cis-Decalins Angew. Chem. 2020, 59, 253-258 61. Adam A.H. Elmehriki and James L. Gleason A Spiroalkylation Method for the Stereoselective Construction of alpha-Quaternary Carbons and Its Application to the Total Synthesis of (R)-Puraquinonic Acid Org. Lett. 2019, 21, 9729-9733 60. Jonathan M. E. Hughes, David A. Scarlata, Austin C.-Y. Chen, Jason D. Burch and James L. Gleason Aminoalkylation of [1.1.1]Propellane Enables Direct Access to High-Value 3-Alkylbicyclo[1.1.1]pentan-1-amines. Org. Lett. 2019, 21, 6800-6804 59. Nicklas Haggman, Benjamin Zank, HyunJune Jun, Dainis Kaldre and James L. Gleason Diazepane carboxylates as organocatalysts in the Diels-Alder reaction of alpha-substituted enals Eur. J. Org. Chem., 2018, 5412-5416 58. Anthony F. Palermo, Marine Diennet, Mohamed El Ezzy, Benjamin M Williams, David Cotnoir-White, Sylvie Mader and James L. Gleason Incorporation of histone deacetylase inhibitor activity into the core of tamoxifen - a new hybrid design paradigm. Bioorg. Med. Chem. 2018, 26, 4428-4440 57. Branca M. Cavaco, Lucie Canaff, Alexis Nolin-Lapalme, Margarida Vieira, Tiago Silva, Ana Saramago, Rita Domingues, Meilan M. Rutter, Jonathan Hudon, James L. Gleason, Valeriano Leite, Geoffrey N. Hendy Homozygous calcium-sensing receptor polymorphism R544Q presents as hypocalcemic hypoparathyroidism  J. Clin. Endo. Met. 2018, 103, 2879-2888 56. Jonathan M.E. Hughes and James L. Gleason A bio-inspired cascade and a late-stage directed sp3- C-H lithiation enables a concise total synthesis of (-)-virosaine A. Tetrahedron, 2018 74, 759-768 55. Krikor Bijian, Dainis Kaldre, Tian-Tian Wang, Manuella Bouttier, Annie Boucher, Moulay Alaoui-Jamali, John. H. White and James L. Gleason Efficacy of Hybrid Vitamin D Receptor Agonist/Histone Deacetylase Inhibitors in Vitamin D-Resistant Triple-Negative 4T1 Breast Cancer J. Steroid Biochem. Mol. Biol. 2018, 177, 135-139 54. James L. Gleason and John H. White Bifunctional Vitamin D. Hybrid Molecules Vitamin D: 4th edition. Feldmen, Pike, Bouillon, Givannucci, Goltzman, Hewison, eds., Academic Press, 2018, 647-655 55. Johnathan M. E. Hughes and James L. Gleason A Concise, Enantioselective Total Synthesis of (–)-Virosaine A Angew. Chem. Int. Ed., 2017, 56, 10830-10834 For a highlight of this work, see: Angew. Chem. Int. Ed. 2017, 45, 13940-13942 52. Florent Larnaud, Adamo Sulpizi, Nicklas O. Häggman, Jonathan M.E. Hughes, Damien F. Dewez and James L. Gleason Organocatalytic Michael Addition of Indoles to alpha-Substituted Enals Using a Diazepane Carboxylate Catalyst Eur. J. Org. Chem. 2017, 18, 2637-2640 51. Dainis Kaldre and James L. Gleason An Organocatalytic Cope Rearrangement Angew. Chem., 2016, 55, 11557-115561 For a highlight of this work, see: Angew. Chem. Int. Ed. 2016, 55, 14208-14209 50. Tatiana Traboulsi, Mohamed El Ezzy, James L. Gleason, Sylvie Mader Mechanisms of Action of Antiestrogens: Impact on Clinical Use J. Mol. Endo., 2017, 58, R15-31 49. Lee D. Fader, Martine Brault, Jessica Desjardins, Nathalie Dansereau, Louie Lamorte, Sonia Tremblay, François Bilodeau, Josée Bordeleau, Martin Duplessis, Vida Gorys, James R. Gillard, James L Gleason, Clint James, Marc-André Joly, Cyrille Kuhn, Montse Llinas-Brunet, Laibin Luo, Louis Morency, Sébastien Morin, Mathieu Parisien, Maude Poirier, Carl Thibeault, Thao Trinh, Claudio Sturino, Sanjay Srivastava, Christiane Yoakim, and Michael Franti Discovery of Potent, Orally Bioavailable Inhibitors of Human Cytomegalovirus ACS Med. Chem. Lett., 2016, 7, 525-530 48. Rodrigo Mendoza-Sanchez, David Cotnoir-White, Justyna Kulpa, Isabel Jutras, Joshua Pottel, Nicolas Moitessier, Sylvie Mader and James L. Gleason Design, Synthesis and Evaluation of Antiestrogen and Histone Deacetylase Inhibitor Molecular Hybrids Bioorg. Med. Chem. 2015, 24, 7597-7606 47. Dainis Kaldre, Tian-Tian Wang, Joshua Fischer, John H. White and James L. Gleason Optimization of Histone Deacetylase Inhibitor Activity in Non-Secosteroidal Vitamin D Receptor Agonist Hybrids Bioorg. Med. Chem., 2015, 23, 5035-5049   46. Shuo Xing and James L. Gleason A Robust Synthesis of N-Glycolyl Muramyl Dipeptide via Azidonitration/Reduction Org. Biomol. Chem. 2015, 13, 1515-1520 45. Nicolas De Rycke, Jeffrey D. St Denis, Jonathan M.E. Hughes, Kristopher A. Rosadiuk and James L. Gleason Direct Intramolecular Catalytic Enantioselective Alkylation of Oxazolidinone Bomoalkanoate Imides Synlett, 2014, 25, 2802-2805 44. Joshua Pottel, Eric Therrien, James L. Gleason and Nicolas Moitessier Docking Ligands into Flexible and Solvated Macromolecules. 6. Development and Application to the Docking of HDACs and other Zinc Mettaloenzyme Inhibitors J. Chem. Info. Model. 2014, 54, 254-265 43. Erica Tiong, Daniel Rivalti, Benjamin M. Williams and James L. Gleason A Concise Total Synthesis of (R)-Puraquinonic Acid. Angew. Chem. Int. Ed., 2013, 52, 3442-3445 42. Kyle F. Biegasiewicz, Michelle L. Ingalsbe, Jeffrey D. St. Denis, James L. Gleason, Junming Ho, Michelle L. Coote, G. Paul Savage and Ronny Priefer Evaluation of a chiral cubane-based Schiff base ligand in asymmetric catalysis reactions Beilstien J. Org. Chem. 2012, 8, 1814-1818 41. Khalid Hilmi, Nader Hussein, Rodrigo Mendoza-Sanchez, Mohammed El-Ezzy, Houssam, Ismail, Chantal Durette, Martine Bail, Maria Johanna Rozendaal, Michel Bouver, Pierre Thibault, James L. Gleason and Sylvie Mader Role of SUMOylation in full antiestrogenicity Molecular and Cellular Biology 2012, 32, 3823-3837 40. Joshua Fischer, Tian-Tian Wang, Dainis Kaldre, Natacha Rochel, Dino Moras, John H. White and James L. Gleason Synthetically accessible non-secosteroidal hybrid molecules combining vitamin D receptor agonism and histone deacetylase inhibition Chemistry and Biology, 2012, 19, 963-971. 39. Erica Tiong and James L. Gleason Section 20.2.1.8.14: Synthesis of Carboxylic acids: alpha-alkylation Science of Synthesis 2011, 4, 283-299. 38. Marc Lamblin, Russell Spingarn, Tian-Tian Wang, Melanie C.Burger, Basel Dabbas, Nicolas Moitessier, John H. White and James L. Gleason An o-aminoanilide analog of 1-alpha,25-dihydroxyvitamin D3 functions as a strong vitamin D receptor antagonist. J. Med. Chem. 2010, 53, 7461-7465. 37. Marc Lamblin, Basel Dabbas, Russell Spingarn, Rodrigo Mendoza-Sanchez, Tian-Tian Wang, Beum-Soo An, Dao Chao Huang, Richard Kremer, John H. White and James L. Gleason. Vitamin D Receptor Agonists/Histone Deacetylase Inhibitor Molecular Hybrids Bioorg. Med. Chem. 2010, 18, 4119-4137. 36. James A. Ashenhurst, Ljubomir Isakovic and James L. Gleason Application of a [6+4] cycloaddition strategy toward the total synthesis of CP-225,917 Tetrahedron 2010, 66, 368-378. 35. Michelle L. Ingalsbe, Jeffrey D. St. Denis, James L. Gleason, Paul G. Savage, Ronny Priefer,  Synthesis of novel chiral cubane-based Schiff-base ligand and it's application in asymmetric nitro aldol (Henry) reaction Synthesis 2010, 98-102. 34. Francois Coulombe, Maziar Divangahi, Frederic Veyrier, James L. Gleason, Yibin Yang, Michelle A. Kelliher, Amit K. Pandey, Christopher M. Sassetti, Michael B. Reed, Marcel A. Behr Increased NOD2-Mediated Recognition of N-Glycolylated Muramyl Dipeptide J. Exper. Med. 2009, 206, 1709-1716. 33. Erica A. Tiong and James L. Gleason Stereoselective Formation of alpha-Quaternary Stereocenters in the Mannich Reaction. Org. Lett. 2009, 11, 1725-1728 32. Jonathan Hudon, Timothy A. Cernak, James A. Ashenhurst and James L. Gleason Stable 5-Substituted Cyclopentadienes for the Diels-Alder Cycloaddition and their Application to Palauamine Synthesis Angew. Chem. Int. Ed. 2008, 47, 8885-8888 31. Luz E. Tavera-Mendoza, Tan D. Quach, Basel Dabbas, Jonathan Hudon, Xiaohong Liao, Ana Palijan James L. Gleason and John H. White Incorporation of histone deacetylase inhibition into the structure of a nuclear receptor agonist. Proc. Nat. Acad. Sci. 2008, 105, 8250-8255 30. James A. Ashenhurst and James L. Gleason CP-225,917 Synthetic Studies: Unusual Hydroboration Regioselectivity Influenced by Remote Functional Groups Tetrahedron Lett. 2008, 49, 504-507 29. Timothy Cernak and James L. Gleason Density Functional Theory Guided Design of Exo-Selective Dehydroalanine Dienophiles for Application Towards the Synthesis of Palau'amine J.Org. Chem. 2008, 73, 102-110. 28. Timothy Cernak and James L. Gleason Synthesis of 5-Chloromethylene Hydantoins and Thiohydantoins Heterocycles 2007, 71, 117-134 27. Azélie Arpin, Jeffrey M. Manthorpe and James L. Gleason A Practical Bicylic Lactam Auxiliary for Quaternary Carbon Formation Organic Letters, 2006, 8, 1359-1362 26. Jeremy D. Cheeseman, Andrew D. Corbett, James L. Gleason* and Romas J. Kazlauskas* Receptor-Assisted Combinatorial Chemistry: Thermodynamics and Kinetics in the Discovery of Tight-Binding Molecules Chem. Eur. J., 2005, 11, 1708-1716 25. E. Diane Burke and James L. Gleason alpha,alpha-Disubstituted Boron Enolates in the Asymmetric Synthesis of Quaternary Carbon Centers Org. Lett., 2004, 6, 405-407 24. James L. Gleason and Alain Ajamian Two Birds with One Metallic Stone: Single-Pot Catalysis of Fundamentally Different Transformations Angew. Chem. Int. Ed., 2004, 43, 3754-3760 23. Andrew D. Corbett, Jeremy D. Cheeseman, Romas J. Kazlauskas* and James L. Gleason* Pseudo-Dynamic Combinatorial Libraries: A New Receptor-Assisted Combinatorial Approach for Drug Discovery Angew. Chem. Int. Ed., 2004, 43, 2432-2436 22. Alain Ajamian and James L. Gleason Cobalt Catalyzed Cycloisomerizations of 1,6-Enynes and Allyl Propargyl Ethers Organic Letters, 2003, 5, 2409-2411. 21. E. Diane Burke, Ngiap Kie Lim and James L. Gleason Catalytic Enantioselective Homoaldol Reactions Using Binol Titanium (IV) Fluoride Catalysts Synlett, 2003, 390-392 20. Jeffrey M. Manthorpe and James L. Gleason  Stereoselective Formation of Quaternary Carbon Centres: Alkylation of alpha,alpha-Disubstituted Amide Enolates Angew. Chem. Int. Ed., 2002, 41, 2338-2341. 19. Jeremy D. Cheeseman, Andrew D. Corbett, Ronghua Shu Jonathan Croteau, James L. Gleason* and Romas J. Kazlauskas* Amplification of Screening Sensitivity Through Selective Destruction. Theory and Screening of a Library of Carbonic Anhydrase Inhibitors J. Am. Chem. Soc., 2002, 124, 5692-5701. 18. Andrew D. Corbett and James L. Gleason Preparation of Active Esters on Solid Support for Aqueous Phase Peptide Couplings Tetrahedron Letters, 2002, 43, 1369-1372. 17. Ljubomir Isakovic, James A. Ashenhurst and James L. Gleason  Application of Lewis Acid Catalyzed Tropone [6+4] Cycloadditions to the Synthesis of the Core of CP-225,917 Organic Letters, 2001, 3, 4189-4192 16. Alain Ajamian and James L. Gleason Diastereoselective Synthesis of 2H,5H-Dihydrofurans by Cobalt Mediated Cycloisomerization of Allyl Propargyl Ethers. Application to Poly-THF Molecules Organic Letters, 2001, 3, 4161-4164 \ 15. Jeffrey M. Manthorpe and James L. Gleason Stereoselective Generation of Disubstituted Enolates; Reductive Enolization of Bicylic alpha-Thioglycolate Lactams J. Am. Chem. Soc. 2001, 123, 2091-2092 14. Régis Dolaine and James L. Gleason  Diastereoselective Formation of 5-Vinylcyclopentenes from 1,6-Enynes: Cobalt Mediated C-H Allylic Activation and Formal 5-Endo-Dig Cyclization Organic Letters, 2000, 2, 1753-1756 13. Evelyn O. Martins and James L. Gleason  Titanium (IV) Triflates in the Catalysis of Homoaldol Reactions Organic Letters 1999, 1, 1643-1645 12. Andrew G. Myers and James L. Gleason  Asymmetric Synthesis of alpha-Amino Acids by the Alkylation of Pseudoephedrine Glycinamide. Preparation of L-Allylglycine and N-Boc L-Allylglycine Org. Syn., 1999, 76, 57-76 11. Andrew G. Myers, Lydia McKinstry, Joseph K. Barbay, and James L. Gleason Practical Methodology for the Asymmetric Synthesis of Organofluorine Compounds Tetrahedron Lett. 1998, 39, 1335-1338 10. Andrew G. Myers, Lydia McKinstry and James L. Gleason Synthesis of Tertiary Alkyl Fluoride Centers by Asymmetric C-C(F) Bond Formation Tetrahedron Lett., 1997, 38, 7037-7040 9. Robert E. Ireland, Longbin Liu, Thomas D. Roper and James L. Gleason Total Synthesis of FK-506. 2. Completion of the Synthesis Tetrahedron, 1997, 53, 13257-13284 8. Andrew G. Myers, Bryant H. Yang, Hou Chen, Lydia Mckinstry, David J. Kopecky and James L. Gleason Pseudoephedrine as a Practical Chiral Auxiliary for the Synthesis of Highly Enantiomerically Enriched Carboxylic Acids, Alcohols, Aldehydes and Ketones J. Am. Chem. Soc., 1997, 119, 6496-6511 7. Andrew G. Myers, James L. Gleason, Taeyoung Yoon, and Daniel W. Kung Highly Practical Methodology for the Synthesis of D- and L- alpha-Amino Acids, N-Protected alpha-Amino Acids, and N-Methyl alpha-Amino Acids J. Am. Chem. Soc., 1997, 119, 656-673 6. Robert E. Ireland, James L. Gleason, Laura D. Gegnas and Thomas K. Highsmith A Total Synthesis of FK-506 J. Org. Chem. 1996, 61, 6856-6872 5. Andrew G. Myers and James L. Gleason A Practical Synthesis of Azatyrosine J. Org. Chem. 1996, 61, 813-815 4. Andrew G. Myers, James L. Gleason and Taeyoung Yoon A Practical Method for the Synthesis of D- or L-alpha-Amino Acids by the Alkylation of (+)- or ()-Pseudoephedrine Glycinamide J. Am. Chem. Soc. 1995, 117, 8488-8489 3. Andrew G. Myers, Taeyoung Yoon and James L. Gleason A One-Step Synthesis of Pseudoephedrine Glycinamide, a Versatile Precursor for the Synthesis of alpha-Amino Acids Tetrahedron Lett. 1995, 36, 4555-4558 2. Andrew G. Myers, Bryant H. Yang, Hou Chen and James L. Gleason Use of Pseudoephedrine as a Practical Auxiliary Asymmetric Synthesis J. Am. Chem. Soc. 1994, 116, 9361-9362 1. Robert E. Ireland, Thomas K. Highsmith, Laura D. Gegnas James L. Gleason Synthesis of the 9,10-Acetonide of 9-Dihydro-FK-506 J. Org. Chem. 1992, 57, 5071-5073

70. Josephine M. Warnica and James. L. Gleason
Mimicking enzymatic cation–π interactions in hydrazide catalyst design: access to trans-decalin frameworks
Chem. Commun. 2023, Advance Article

69. Ryan R. G. Barrett, Donald A. Campbell and James L. Gleason
An Organocatalytic oxy-Cope/Michael cascade Reaction
Org. Lett. 2023, 25, 777-781

68. Anthony R. Izzotti and James L. Gleason
Do Antarafacial Cycloadditions Occur? Cycloaddition of Heptafulvalene with Tetracyanoethylene.
Chem. Eur. J. 2022, 28, e202201418

67. Camille Barbier, Ali Mansour, Aiten Ismailova, Parvaneh Sarmadi, David A. Scarlata, Manuella Bouttier, Camille Zeitouni, Catherine Wang, James L. Gleason and John H. White
Molecular mechanisms of bifunctional vitamin D receptor agonist-histone deacetylase inhibitor hybrid molecules in triple-negative breast cancer.
Scientific Reports 2022, 12, 6745-6757

66. Samuel J. Plamondon and James L. Gleason
Total Synthesis of (–)-3-Oxoisotaxodione
Org. Lett. 2022, 24, 2305-2309

65. Josephine M. Warnica and James L. Gleason
The Stabilized Iminium Catalyzed (E)-Polyene Cyclization: Trapping of Non-Activated Terminating Groups Enabled by Cation-π Interactions
Can. J. Chem. 2022, 100, 212-216

64. Ryan R.G. Barrett, Claire Nash, Marine Diennet, David Cotnoir-White, Christopher Doyle, Sylvie Mader, Axel A. Thomson, James L. Gleason
Dual-function antiandrogen/HDACi hybrids based on enzalutamide and entinostat
Bioorg. Med. Chem. Lett. 2022, 55, 128441

63. Jacob N. Sanders, HyunJune Jun, Roland A. Yu, James L. Gleason and K. N. Houk
Mechanism of an Organocatalytic Cope Rearrangement Involving Iminium Intermediates: Elucidating the Role of Catalyst Ring Size
J. Am. Chem. Soc. 2020, 142, 16877-16886

62. Samuel J. Plamondon, Josephine M. Warnica, Dainis Kaldre and James L. Gleason
Hydrazide-Catalyzed Polyene Cyclization: Asymmetric Organocatalytic Synthesis of cis-Decalins
Angew. Chem. 2020, 59, 253-258

61. Adam A.H. Elmehriki and James L. Gleason
A Spiroalkylation Method for the Stereoselective Construction of alpha-Quaternary Carbons and Its Application to the
Total Synthesis of (R)-Puraquinonic Acid
Org. Lett. 2019, 21, 9729-9733

60. Jonathan M. E. Hughes, David A. Scarlata, Austin C.-Y. Chen, Jason D. Burch and James L. Gleason
Aminoalkylation of [1.1.1]Propellane Enables Direct Access to High-Value 3-Alkylbicyclo[1.1.1]pentan-1-amines.
Org. Lett. 2019, 21, 6800-6804

59. Nicklas Haggman, Benjamin Zank, HyunJune Jun, Dainis Kaldre and James L. Gleason
Diazepane carboxylates as organocatalysts in the Diels-Alder reaction of alpha-substituted enals
Eur. J. Org. Chem., 2018, 5412-5416

58. Anthony F. Palermo, Marine Diennet, Mohamed El Ezzy, Benjamin M Williams, David Cotnoir-White, Sylvie Mader and James L. Gleason
Incorporation of histone deacetylase inhibitor activity into the core of tamoxifen - a new hybrid design paradigm.
Bioorg. Med. Chem. 2018, 26, 4428-4440

57. Branca M. Cavaco, Lucie Canaff, Alexis Nolin-Lapalme, Margarida Vieira, Tiago Silva, Ana Saramago, Rita Domingues, Meilan M. Rutter, Jonathan Hudon, James L. Gleason, Valeriano Leite, Geoffrey N. Hendy
Homozygous calcium-sensing receptor polymorphism R544Q presents as hypocalcemic hypoparathyroidism
J. Clin. Endo. Met. 2018, 103, 2879-2888

56. Jonathan M.E. Hughes and James L. Gleason
A bio-inspired cascade and a late-stage directed sp3- C-H lithiation enables a concise total synthesis of (-)-virosaine A.
Tetrahedron, 2018 74, 759-768

55. Krikor Bijian, Dainis Kaldre, Tian-Tian Wang, Manuella Bouttier, Annie Boucher, Moulay Alaoui-Jamali, John. H. White and James L. Gleason
Efficacy of Hybrid Vitamin D Receptor Agonist/Histone Deacetylase Inhibitors in Vitamin D-Resistant Triple-Negative 4T1 Breast Cancer
J. Steroid Biochem. Mol. Biol. 2018, 177, 135-139

54. James L. Gleason and John H. White
Bifunctional Vitamin D. Hybrid Molecules
Vitamin D: 4th edition. Feldmen, Pike, Bouillon, Givannucci, Goltzman, Hewison, eds., Academic Press, 2018, 647-655

55. Johnathan M. E. Hughes and James L. Gleason
A Concise, Enantioselective Total Synthesis of (–)-Virosaine A
Angew. Chem. Int. Ed., 2017, 56, 10830-10834

For a highlight of this work, see: Angew. Chem. Int. Ed. 2017, 45, 13940-13942

52. Florent Larnaud, Adamo Sulpizi, Nicklas O. Häggman, Jonathan M.E. Hughes, Damien F. Dewez and James L. Gleason
Organocatalytic Michael Addition of Indoles to alpha-Substituted Enals Using a Diazepane Carboxylate Catalyst
Eur. J. Org. Chem. 2017, 18, 2637-2640

51. Dainis Kaldre and James L. Gleason
An Organocatalytic Cope Rearrangement
Angew. Chem., 2016, 55, 11557-115561

For a highlight of this work, see: Angew. Chem. Int. Ed. 2016, 55, 14208-14209

50. Tatiana Traboulsi, Mohamed El Ezzy, James L. Gleason, Sylvie Mader
Mechanisms of Action of Antiestrogens: Impact on Clinical Use
J. Mol. Endo., 2017, 58, R15-31

49. Lee D. Fader, Martine Brault, Jessica Desjardins, Nathalie Dansereau, Louie Lamorte, Sonia Tremblay, François Bilodeau, Josée Bordeleau, Martin Duplessis, Vida Gorys, James R. Gillard, James L Gleason, Clint James, Marc-André Joly, Cyrille Kuhn, Montse Llinas-Brunet, Laibin Luo, Louis Morency, Sébastien Morin, Mathieu Parisien, Maude Poirier, Carl Thibeault, Thao Trinh, Claudio Sturino, Sanjay Srivastava, Christiane Yoakim, and Michael Franti
Discovery of Potent, Orally Bioavailable Inhibitors of Human Cytomegalovirus
ACS Med. Chem. Lett., 2016, 7, 525-530

48. Rodrigo Mendoza-Sanchez, David Cotnoir-White, Justyna Kulpa, Isabel Jutras, Joshua Pottel, Nicolas Moitessier, Sylvie Mader and James L. Gleason
Design, Synthesis and Evaluation of Antiestrogen and Histone Deacetylase Inhibitor Molecular Hybrids
Bioorg. Med. Chem. 2015, 24, 7597-7606

47. Dainis Kaldre, Tian-Tian Wang, Joshua Fischer, John H. White and James L. Gleason
Optimization of Histone Deacetylase Inhibitor Activity in Non-Secosteroidal Vitamin D Receptor Agonist Hybrids
Bioorg. Med. Chem., 2015, 23, 5035-5049

46. Shuo Xing and James L. Gleason
A Robust Synthesis of N-Glycolyl Muramyl Dipeptide via Azidonitration/Reduction
Org. Biomol. Chem. 2015, 13, 1515-1520

45. Nicolas De Rycke, Jeffrey D. St Denis, Jonathan M.E. Hughes, Kristopher A. Rosadiuk and James L. Gleason
Direct Intramolecular Catalytic Enantioselective Alkylation of Oxazolidinone Bomoalkanoate Imides
Synlett, 2014, 25, 2802-2805

44. Joshua Pottel, Eric Therrien, James L. Gleason and Nicolas Moitessier
Docking Ligands into Flexible and Solvated Macromolecules. 6. Development and Application to the Docking of HDACs and other Zinc Mettaloenzyme Inhibitors
J. Chem. Info. Model. 2014, 54, 254-265

43. Erica Tiong, Daniel Rivalti, Benjamin M. Williams and James L. Gleason
A Concise Total Synthesis of (R)-Puraquinonic Acid.
Angew. Chem. Int. Ed., 2013, 52, 3442-3445

42. Kyle F. Biegasiewicz, Michelle L. Ingalsbe, Jeffrey D. St. Denis, James L. Gleason, Junming Ho, Michelle L. Coote, G. Paul Savage and Ronny Priefer
Evaluation of a chiral cubane-based Schiff base ligand in asymmetric catalysis reactions
Beilstien J. Org. Chem. 2012, 8, 1814-1818

41. Khalid Hilmi, Nader Hussein, Rodrigo Mendoza-Sanchez, Mohammed El-Ezzy, Houssam, Ismail, Chantal Durette, Martine Bail, Maria Johanna Rozendaal, Michel Bouver, Pierre Thibault, James L. Gleason and Sylvie Mader
Role of SUMOylation in full antiestrogenicity
Molecular and Cellular Biology 2012, 32, 3823-3837

40. Joshua Fischer, Tian-Tian Wang, Dainis Kaldre, Natacha Rochel, Dino Moras, John H. White and James L. Gleason
Synthetically accessible non-secosteroidal hybrid molecules combining vitamin D receptor agonism and histone deacetylase inhibition
Chemistry and Biology, 2012, 19, 963-971.

39. Erica Tiong and James L. Gleason
Section 20.2.1.8.14: Synthesis of Carboxylic acids: alpha-alkylation
Science of Synthesis 2011, 4, 283-299.

38. Marc Lamblin, Russell Spingarn, Tian-Tian Wang, Melanie C.Burger, Basel Dabbas, Nicolas Moitessier, John H. White and James L. Gleason
An o-aminoanilide analog of 1-alpha,25-dihydroxyvitamin D3 functions as a strong vitamin D receptor antagonist.
J. Med. Chem. 2010, 53, 7461-7465.

37. Marc Lamblin, Basel Dabbas, Russell Spingarn, Rodrigo Mendoza-Sanchez, Tian-Tian Wang, Beum-Soo An, Dao Chao Huang, Richard Kremer, John H. White and James L. Gleason.
Vitamin D Receptor Agonists/Histone Deacetylase Inhibitor Molecular Hybrids
Bioorg. Med. Chem. 2010, 18, 4119-4137.

36. James A. Ashenhurst, Ljubomir Isakovic and James L. Gleason
Application of a [6+4] cycloaddition strategy toward the total synthesis of CP-225,917
Tetrahedron 2010, 66, 368-378.

35. Michelle L. Ingalsbe, Jeffrey D. St. Denis, James L. Gleason, Paul G. Savage, Ronny Priefer,
Synthesis of novel chiral cubane-based Schiff-base ligand and it's application in asymmetric nitro aldol (Henry) reaction
Synthesis 2010, 98-102.

34. Francois Coulombe, Maziar Divangahi, Frederic Veyrier, James L. Gleason, Yibin Yang, Michelle A. Kelliher, Amit K. Pandey, Christopher M. Sassetti, Michael B. Reed, Marcel A. Behr
Increased NOD2-Mediated Recognition of N-Glycolylated Muramyl Dipeptide
J. Exper. Med. 2009, 206, 1709-1716.

33. Erica A. Tiong and James L. Gleason
Stereoselective Formation of alpha-Quaternary Stereocenters in the Mannich Reaction.
Org. Lett. 2009, 11, 1725-1728

32. Jonathan Hudon, Timothy A. Cernak, James A. Ashenhurst and James L. Gleason
Stable 5-Substituted Cyclopentadienes for the Diels-Alder Cycloaddition and their Application to Palauamine Synthesis
Angew. Chem. Int. Ed. 2008, 47, 8885-8888

31. Luz E. Tavera-Mendoza, Tan D. Quach, Basel Dabbas, Jonathan Hudon, Xiaohong Liao, Ana Palijan James L. Gleason and John H. White
Incorporation of histone deacetylase inhibition into the structure of a nuclear receptor agonist.
Proc. Nat. Acad. Sci. 2008, 105, 8250-8255

30. James A. Ashenhurst and James L. Gleason
CP-225,917 Synthetic Studies: Unusual Hydroboration Regioselectivity Influenced by Remote Functional Groups
Tetrahedron Lett. 2008, 49, 504-507

29. Timothy Cernak and James L. Gleason
Density Functional Theory Guided Design of Exo-Selective Dehydroalanine Dienophiles for Application Towards the Synthesis of Palau'amine
J.Org. Chem. 2008, 73, 102-110.

28. Timothy Cernak and James L. Gleason
Synthesis of 5-Chloromethylene Hydantoins and Thiohydantoins
Heterocycles 2007, 71, 117-134

27. Azélie Arpin, Jeffrey M. Manthorpe and James L. Gleason
A Practical Bicylic Lactam Auxiliary for Quaternary Carbon Formation
Organic Letters, 2006, 8, 1359-1362

26. Jeremy D. Cheeseman, Andrew D. Corbett, James L. Gleason* and Romas J. Kazlauskas*
Receptor-Assisted Combinatorial Chemistry: Thermodynamics and Kinetics in the Discovery of Tight-Binding Molecules
Chem. Eur. J., 2005, 11, 1708-1716

25. E. Diane Burke and James L. Gleason
alpha,alpha-Disubstituted Boron Enolates in the Asymmetric Synthesis of Quaternary Carbon Centers
Org. Lett., 2004, 6, 405-407

24. James L. Gleason and Alain Ajamian
Two Birds with One Metallic Stone: Single-Pot Catalysis of Fundamentally Different Transformations
Angew. Chem. Int. Ed., 2004, 43, 3754-3760

23. Andrew D. Corbett, Jeremy D. Cheeseman, Romas J. Kazlauskas* and James L. Gleason*
Pseudo-Dynamic Combinatorial Libraries: A New Receptor-Assisted Combinatorial Approach for Drug Discovery
Angew. Chem. Int. Ed., 2004, 43, 2432-2436

22. Alain Ajamian and James L. Gleason
Cobalt Catalyzed Cycloisomerizations of 1,6-Enynes and Allyl Propargyl Ethers
Organic Letters, 2003, 5, 2409-2411.

21. E. Diane Burke, Ngiap Kie Lim and James L. Gleason
Catalytic Enantioselective Homoaldol Reactions Using Binol Titanium (IV) Fluoride Catalysts
Synlett, 2003, 390-392

20. Jeffrey M. Manthorpe and James L. Gleason
Stereoselective Formation of Quaternary Carbon Centres: Alkylation of alpha,alpha-Disubstituted Amide Enolates
Angew. Chem. Int. Ed., 2002, 41, 2338-2341.

19. Jeremy D. Cheeseman, Andrew D. Corbett, Ronghua Shu Jonathan Croteau, James L. Gleason* and Romas J. Kazlauskas*
Amplification of Screening Sensitivity Through Selective Destruction. Theory and Screening of a Library of Carbonic Anhydrase Inhibitors
J. Am. Chem. Soc., 2002, 124, 5692-5701.

18. Andrew D. Corbett and James L. Gleason
Preparation of Active Esters on Solid Support for Aqueous Phase Peptide Couplings
Tetrahedron Letters, 2002, 43, 1369-1372.

17. Ljubomir Isakovic, James A. Ashenhurst and James L. Gleason
Application of Lewis Acid Catalyzed Tropone [6+4] Cycloadditions to the Synthesis of the Core of CP-225,917
Organic Letters, 2001, 3, 4189-4192

16. Alain Ajamian and James L. Gleason
Diastereoselective Synthesis of 2H,5H-Dihydrofurans by Cobalt Mediated Cycloisomerization of Allyl Propargyl Ethers. Application to Poly-THF Molecules
Organic Letters, 2001, 3, 4161-4164

15. Jeffrey M. Manthorpe and James L. Gleason
Stereoselective Generation of Disubstituted Enolates; Reductive Enolization of Bicylic alpha-Thioglycolate Lactams
J. Am. Chem. Soc. 2001, 123, 2091-2092

14. Régis Dolaine and James L. Gleason
Diastereoselective Formation of 5-Vinylcyclopentenes from 1,6-Enynes: Cobalt Mediated C-H Allylic Activation and Formal 5-Endo-Dig Cyclization
Organic Letters, 2000, 2, 1753-1756

13. Evelyn O. Martins and James L. Gleason
Titanium (IV) Triflates in the Catalysis of Homoaldol Reactions
Organic Letters 1999, 1, 1643-1645

12. Andrew G. Myers and James L. Gleason
Asymmetric Synthesis of alpha-Amino Acids by the Alkylation of Pseudoephedrine Glycinamide. Preparation of L-Allylglycine and N-Boc L-Allylglycine
Org. Syn., 1999, 76, 57-76

11. Andrew G. Myers, Lydia McKinstry, Joseph K. Barbay, and James L. Gleason
Practical Methodology for the Asymmetric Synthesis of Organofluorine Compounds
Tetrahedron Lett. 1998, 39, 1335-1338

10. Andrew G. Myers, Lydia McKinstry and James L. Gleason
Synthesis of Tertiary Alkyl Fluoride Centers by Asymmetric C-C(F) Bond Formation
Tetrahedron Lett., 1997, 38, 7037-7040

9. Robert E. Ireland, Longbin Liu, Thomas D. Roper and James L. Gleason
Total Synthesis of FK-506. 2. Completion of the Synthesis
Tetrahedron, 1997, 53, 13257-13284

8. Andrew G. Myers, Bryant H. Yang, Hou Chen, Lydia Mckinstry, David J. Kopecky and James L. Gleason
Pseudoephedrine as a Practical Chiral Auxiliary for the Synthesis of Highly Enantiomerically Enriched Carboxylic Acids, Alcohols, Aldehydes and Ketones
J. Am. Chem. Soc., 1997, 119, 6496-6511

7. Andrew G. Myers, James L. Gleason, Taeyoung Yoon, and Daniel W. Kung
Highly Practical Methodology for the Synthesis of D- and L- alpha-Amino Acids, N-Protected alpha-Amino Acids, and N-Methyl alpha-Amino Acids
J. Am. Chem. Soc., 1997, 119, 656-673

6. Robert E. Ireland, James L. Gleason, Laura D. Gegnas and Thomas K. Highsmith
A Total Synthesis of FK-506
J. Org. Chem. 1996, 61, 6856-6872

5. Andrew G. Myers and James L. Gleason
A Practical Synthesis of Azatyrosine
J. Org. Chem. 1996, 61, 813-815

4. Andrew G. Myers, James L. Gleason and Taeyoung Yoon
A Practical Method for the Synthesis of D- or L-alpha-Amino Acids by the Alkylation of (+)- or ()-Pseudoephedrine Glycinamide
J. Am. Chem. Soc. 1995, 117, 8488-8489

3. Andrew G. Myers, Taeyoung Yoon and James L. Gleason
A One-Step Synthesis of Pseudoephedrine Glycinamide, a Versatile Precursor for the Synthesis of alpha-Amino Acids
Tetrahedron Lett. 1995, 36, 4555-4558

2. Andrew G. Myers, Bryant H. Yang, Hou Chen and James L. Gleason
Use of Pseudoephedrine as a Practical Auxiliary Asymmetric Synthesis
J. Am. Chem. Soc. 1994, 116, 9361-9362

1. Robert E. Ireland, Thomas K. Highsmith, Laura D. Gegnas James L. Gleason
Synthesis of the 9,10-Acetonide of 9-Dihydro-FK-506
J. Org. Chem. 1992, 57, 5071-5073

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